Ellie Walker arrives in Mayberry to take over her uncle’s drugstore. Some townspeople, especially a busybody named Emma Watson, aren’t happy with a woman running things.

A dangerous criminal escapes in the area, prompting the state police to descend on Mayberry for a manhunt. They dismiss Andy’s laid-back

Jim Lindsey, a shy young man from Mayberry, returns home with exceptional guitar talent. Andy encourages him to play in public

In the pilot episode, Andy's beloved Aunt Bee comes to live with him and Opie to help raise the young boy. Opie resists the change at first